The ony clue I can offer is . Avir and Zune and NOD32 all do something with the virtual keys in Vist. this is ONLY a theroy so if it proves otherwise then so be it , but my current theroy is that Vista handles system paths and registry keys somewhat differently than any incarnation of windows before .. and some programs , or combinations of programs can get into trouble when the stars are aligned properly .. the only way I determined this was by doing a clean install of my system and didnt connect it to the internet or anything , just fresh windows vista ultimate ... then installed Cs3 Master suite .. I have a specific file that I know causes this issue ... it was fine with the clean install ... then , in this case , I installed NOD32 .. problem came right away .. disabled NOD32 when I wanted to save and it worked fine . Mind you I didnt need to UNINSTALL I just needed to disabled it for 30 seconds while I saved my file ... reenabling NOD 32 brought the issue back , disabling problem gone ... I then went ahead and installed all my other softwares , office 2007 , software and drivers for my logitech webcam , BRother MFD , chipset and graphics card drivers ( nividia ) , Spybot search and destroy , Spywareblaster , Adaware , various other bits and bobs ... I then added SP1 to vista and whent online and did all the current updadstes for office and windows , and lastly I updated all my adobe products through adobe updater .. I prefere foxit over adobe reader , so I added that as well ... So now I went to test the issue with savign in illustrator and it is gone ... so hey what the hell ? I am guessing some combination of softwares in my system has worked round the combination of softwares that was causing the issue .. it makes it much harder to track this bug due to it is no longer reproducable on my system ... maybee I will pay round with a Virtual machine or something , but to be honest it is quite a task to wipe and rebuild my machine just to do the testing that I think somebody at Adobe must be getting a paycheck to do :)